GHEUENS SARAH (Chief Medical Officer) sold 5.2% of their position (4.05K shares) of AGIOS PHARMACEUTICALS, INC. on the open market

Open‑market sale worth $117.4K — a moderate reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 3 sales

GHEUENS SARAH

Filed: 3/3/2026ACC: 0001439222-26-000040

InsiderGHEUENS SARAHCIK 1881190

→

IssuerAGIOS PHARMACEUTICALS, INC.CIK 1439222

Officer· Chief Medical Officer

Since Sep 2021

+83.94K

Net shares

Net buyer

$117.4K

Total sold

Open market trades

0B · 3S

Total transactions

101.67K acquired · 17.72K disposed

Non-Derivative Transactions6

Common stock

Direct

M · Option Exercise

+4K

Price / share

—

Trade value

—

% of position

6.2%

3/2/2026

64.80K→68.80K

Common stock

Direct

S · Sale

−1.19K

Price / share

$28.96

Trade value

$34.38K

% of position

1.7%

3/2/2026

68.80K→67.61K

Common stock

Direct

M · Option Exercise

+5.67K

Price / share

—

Trade value

—

% of position

8.4%

3/2/2026

67.61K→73.27K

Common stock

Direct

S · Sale

−1.68K

Price / share

$28.96

Trade value

$48.68K

% of position

2.3%

3/2/2026

73.27K→71.59K

Common stock

Direct

M · Option Exercise

+4K

Price / share

—

Trade value

—

% of position

5.6%

3/2/2026

71.59K→75.59K

Common stock

Direct

S · Sale

−1.19K

Price / share

$28.96

Trade value

$34.38K

% of position

1.6%

3/2/2026

75.59K→74.41K

Total

Net shares

+9.61K

Net value

-$117.43K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common stock Direct	3/2/2026	M · Option Exercise	+4K	—	—	6.2%	64.80K	68.80K
Common stock Direct	3/2/2026	S · Sale	−1.19K	$28.96	$34.38K	1.7%	68.80K	67.61K
Common stock Direct	3/2/2026	M · Option Exercise	+5.67K	—	—	8.4%	67.61K	73.27K
Common stock Direct	3/2/2026	S · Sale	−1.68K	$28.96	$48.68K	2.3%	73.27K	71.59K
Common stock Direct	3/2/2026	M · Option Exercise	+4K	—	—	5.6%	71.59K	75.59K
Common stock Direct	3/2/2026	S · Sale	−1.19K	$28.96	$34.38K	1.6%	75.59K	74.41K
Total			+9.61K		-$117.43K

Derivative Transactions6

Restricted stock units

Direct

A · Award

Converts to

Common stock

14K shares

+14K

Strike price

Held after

14K

Exercisable

—

3/1/2026

Restricted stock units

Direct

A · Award

Converts to

Common stock

22K shares

+22K

Strike price

Held after

22K

Exercisable

—

3/1/2026

Stock options (right to buy)

Direct

A · Award

Converts to

Common stock

52K shares

+52K

Strike price

30.23

Held after

52K

Exercisable

—

3/1/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

4K shares

−4K

Strike price

Held after

0.00

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

5.67K shares

−5.67K

Strike price

Held after

5.67K

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

4K shares

−4K

Strike price

Held after

Exercisable

—

3/2/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Restricted stock units Direct	Common stock14K shares	3/1/2026	A · Award	+14K		—	14K
Restricted stock units Direct	Common stock22K shares	3/1/2026	A · Award	+22K		—	22K
Stock options (right to buy) Direct	Common stock52K shares	3/1/2026	A · Award	+52K	30.23	—	52K
Restricted stock units Direct	Common stock4K shares	3/2/2026	M · Option Exercise	−4K		—	0.00
Restricted stock units Direct	Common stock5.67K shares	3/2/2026	M · Option Exercise	−5.67K		—	5.67K
Restricted stock units Direct	Common stock4K shares	3/2/2026	M · Option Exercise	−4K		—	8K