Filed: 11/14/2025ACC: 0001892134-25-000012
📋 What this filing means
FRAZIER LIFE SCIENCES MANAGEMENT, L.P. filed this quarterly 13F‑HR report disclosing 47 equity positions with a total reported market value of $3.34B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
47
Positions
$3.34B
Total AUM (reported)
174.72M
Total Shares
Allocation by class
COM$2.20B66.0%
ORDINARY SHARES$475.00M14.2%
SPONSORED ADS$421.18M12.6%
COM NEW$82.23M2.5%
ADR$55.15M1.7%
SPON ADS$26.98M0.8%
SPONSORED ADR$26.51M0.8%
Portfolio Concentration
Top 3$1.33B40.0%
4–10$984.03M29.5%
11–25$719.43M21.6%
Rest$299.68M9.0%
Top 3 weight
40.0%
Top 10 weight
69.5%
Voting Authority Distribution
Total shares with voting rights: 174.72M
Sole
Full voting authority
174.72M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole47
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings47
Rows:
MIRUM PHARMACEUTICALS INC
SOLEShares6.80M
TypeSH
Market value$498.15M
14.93%
Sole
6.80M
Shared
0.00
None
0.00
NEWAMSTERDAM PHARMA COMPANY
SOLEShares16.70M
TypeSH
Market value$475.00M
14.23%
Sole
16.70M
Shared
0.00
None
0.00
VERONA PHARMA PLC
SOLEShares3.38M
TypeSH
Market value$361.10M
10.82%
Sole
3.38M
Shared
0.00
None
0.00
BRIDGEBIO PHARMA INC
SOLEShares3.85M
TypeSH
Market value$199.73M
5.98%
Sole
3.85M
Shared
0.00
None
0.00
ARCUTIS BIOTHERAPEUTICS INC
SOLEShares9.87M
TypeSH
Market value$186.13M
5.58%
Sole
9.87M
Shared
0.00
None
0.00
PHATHOM PHARMACEUTICALS INC
SOLEShares12.47M
TypeSH
Market value$146.73M
4.40%
Sole
12.47M
Shared
0.00
None
0.00
KRYSTAL BIOTECH INC
SOLEShares688.46K
TypeSH
Market value$121.53M
3.64%
Sole
688.46K
Shared
0.00
None
0.00
MAZE THERAPEUTICS INC
SOLEShares4.57M
TypeSH
Market value$118.43M
3.55%
Sole
4.57M
Shared
0.00
None
0.00
MBX BIOSCIENCES INC
SOLEShares6.65M
TypeSH
Market value$116.41M
3.49%
Sole
6.65M
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.44M
TypeSH
Market value$95.06M
2.85%
Sole
1.44M
Shared
0.00
None
0.00
TREVI THERAPEUTICS INC
SOLEShares10.26M
TypeSH
Market value$93.87M
2.81%
Sole
10.26M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares1.17M
TypeSH
Market value$69.39M
2.08%
Sole
1.17M
Shared
0.00
None
0.00
KALVISTA PHARMACEUTICALS INC
SOLEShares5.04M
TypeSH
Market value$61.39M
1.84%
Sole
5.04M
Shared
0.00
None
0.00
ZAI LAB LTD
SOLEShares1.63M
TypeSH
Market value$55.15M
1.65%
Sole
1.63M
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares1.28M
TypeSH
Market value$51.37M
1.54%
Sole
1.28M
Shared
0.00
None
0.00
ERASCA INC
SOLEShares22.73M
TypeSH
Market value$49.55M
1.48%
Sole
22.73M
Shared
0.00
None
0.00
CYTOKINETICS INC
SOLEShares890.45K
TypeSH
Market value$48.94M
1.47%
Sole
890.45K
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares997.46K
TypeSH
Market value$46.58M
1.40%
Sole
997.46K
Shared
0.00
None
0.00
PALVELLA THERAPEUTICS INC NE
SOLEShares722.40K
TypeSH
Market value$45.29M
1.36%
Sole
722.40K
Shared
0.00
None
0.00
SAVARA INC
SOLEShares11.46M
TypeSH
Market value$40.92M
1.23%
Sole
11.46M
Shared
0.00
None
0.00
DYNE THERAPEUTICS INC
SOLEShares2.72M
TypeSH
Market value$34.38M
1.03%
Sole
2.72M
Shared
0.00
None
0.00
ABIVAX SA
SOLEShares378.30K
TypeSH
Market value$32.12M
0.96%
Sole
378.30K
Shared
0.00
None
0.00
AURA BIOSCIENCES INC
SOLEShares5.10M
TypeSH
Market value$31.52M
0.94%
Sole
5.10M
Shared
0.00
None
0.00
ULTRAGENYX PHARMACEUTICAL IN
SOLEShares983.72K
TypeSH
Market value$29.59M
0.89%
Sole
983.72K
Shared
0.00
None
0.00
LEXEO THERAPEUTICS INC
SOLEShares4.42M
TypeSH
Market value$29.38M
0.88%
Sole
4.42M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MIRUM PHARMACEUTICALS INCSOLE | COM | 6.80M | SH | $498.15M 14.93% | 6.80M | 0.00 | 0.00 |
NEWAMSTERDAM PHARMA COMPANYSOLE | ORDINARY SHARES | 16.70M | SH | $475.00M 14.23% | 16.70M | 0.00 | 0.00 |
VERONA PHARMA PLCSOLE | SPONSORED ADS | 3.38M | SH | $361.10M 10.82% | 3.38M | 0.00 | 0.00 |
BRIDGEBIO PHARMA INCSOLE | COM | 3.85M | SH | $199.73M 5.98% | 3.85M | 0.00 | 0.00 |
ARCUTIS BIOTHERAPEUTICS INCSOLE | COM | 9.87M | SH | $186.13M 5.58% | 9.87M | 0.00 | 0.00 |
PHATHOM PHARMACEUTICALS INCSOLE | COM | 12.47M | SH | $146.73M 4.40% | 12.47M | 0.00 | 0.00 |
KRYSTAL BIOTECH INCSOLE | COM | 688.46K | SH | $121.53M 3.64% | 688.46K | 0.00 | 0.00 |
MAZE THERAPEUTICS INCSOLE | COM | 4.57M | SH | $118.43M 3.55% | 4.57M | 0.00 | 0.00 |
MBX BIOSCIENCES INCSOLE | COM | 6.65M | SH | $116.41M 3.49% | 6.65M | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.44M | SH | $95.06M 2.85% | 1.44M | 0.00 | 0.00 |
TREVI THERAPEUTICS INCSOLE | COM | 10.26M | SH | $93.87M 2.81% | 10.26M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 1.17M | SH | $69.39M 2.08% | 1.17M | 0.00 | 0.00 |
KALVISTA PHARMACEUTICALS INCSOLE | COM | 5.04M | SH | $61.39M 1.84% | 5.04M | 0.00 | 0.00 |
ZAI LAB LTDSOLE | ADR | 1.63M | SH | $55.15M 1.65% | 1.63M | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 1.28M | SH | $51.37M 1.54% | 1.28M | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 22.73M | SH | $49.55M 1.48% | 22.73M | 0.00 | 0.00 |
CYTOKINETICS INCSOLE | COM NEW | 890.45K | SH | $48.94M 1.47% | 890.45K | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 997.46K | SH | $46.58M 1.40% | 997.46K | 0.00 | 0.00 |
PALVELLA THERAPEUTICS INC NESOLE | COM | 722.40K | SH | $45.29M 1.36% | 722.40K | 0.00 | 0.00 |
SAVARA INCSOLE | COM | 11.46M | SH | $40.92M 1.23% | 11.46M | 0.00 | 0.00 |
DYNE THERAPEUTICS INCSOLE | COM | 2.72M | SH | $34.38M 1.03% | 2.72M | 0.00 | 0.00 |
ABIVAX SASOLE | SPONSORED ADS | 378.30K | SH | $32.12M 0.96% | 378.30K | 0.00 | 0.00 |
AURA BIOSCIENCES INCSOLE | COM | 5.10M | SH | $31.52M 0.94% | 5.10M | 0.00 | 0.00 |
ULTRAGENYX PHARMACEUTICAL INSOLE | COM | 983.72K | SH | $29.59M 0.89% | 983.72K | 0.00 | 0.00 |
LEXEO THERAPEUTICS INCSOLE | COM | 4.42M | SH | $29.38M 0.88% | 4.42M | 0.00 | 0.00 |
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