Filed: 8/14/2025ACC: 0001892134-25-000006
📋 What this filing means
FRAZIER LIFE SCIENCES MANAGEMENT, L.P. filed this quarterly 13F‑HR report disclosing 49 equity positions with a total reported market value of $2.50B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
49
Positions
$2.50B
Total AUM (reported)
189.91M
Total Shares
Allocation by class
COM$1.68B67.1%
SPONSORED ADS$328.29M13.1%
ORDINARY SHARES$300.75M12.0%
ADR$45.75M1.8%
COM NEW$38.33M1.5%
SPON ADS$36.12M1.4%
SHS$28.63M1.1%
Portfolio Concentration
Top 3$966.61M38.7%
4–10$729.28M29.2%
11–25$535.90M21.4%
Rest$268.95M10.8%
Top 3 weight
38.7%
Top 10 weight
67.8%
Voting Authority Distribution
Total shares with voting rights: 189.91M
Sole
Full voting authority
189.91M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole49
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings49
Rows:
MIRUM PHARMACEUTICALS INC
SOLEShares6.80M
TypeSH
Market value$345.80M
13.83%
Sole
6.80M
Shared
0.00
None
0.00
VERONA PHARMA PLC
SOLEShares3.38M
TypeSH
Market value$320.05M
12.80%
Sole
3.38M
Shared
0.00
None
0.00
NEWAMSTERDAM PHARMA COMPANY
SOLEShares16.61M
TypeSH
Market value$300.75M
12.03%
Sole
16.61M
Shared
0.00
None
0.00
BRIDGEBIO PHARMA INC
SOLEShares3.80M
TypeSH
Market value$164.10M
6.56%
Sole
3.80M
Shared
0.00
None
0.00
ARCUTIS BIOTHERAPEUTICS INC
SOLEShares9.87M
TypeSH
Market value$138.44M
5.54%
Sole
9.87M
Shared
0.00
None
0.00
PHATHOM PHARMACEUTICALS INC
SOLEShares12.47M
TypeSH
Market value$119.55M
4.78%
Sole
12.47M
Shared
0.00
None
0.00
KRYSTAL BIOTECH INC
SOLEShares688.46K
TypeSH
Market value$94.64M
3.78%
Sole
688.46K
Shared
0.00
None
0.00
DISC MEDICINE INC
SOLEShares1.65M
TypeSH
Market value$87.64M
3.50%
Sole
1.65M
Shared
0.00
None
0.00
MBX BIOSCIENCES INC
SOLEShares5.99M
TypeSH
Market value$68.29M
2.73%
Sole
5.99M
Shared
0.00
None
0.00
TARSUS PHARMACEUTICALS INC
SOLEShares1.40M
TypeSH
Market value$56.61M
2.26%
Sole
1.40M
Shared
0.00
None
0.00
TREVI THERAPEUTICS INC
SOLEShares10.26M
TypeSH
Market value$56.12M
2.24%
Sole
10.26M
Shared
0.00
None
0.00
MAZE THERAPEUTICS INC
SOLEShares4.57M
TypeSH
Market value$56.04M
2.24%
Sole
4.57M
Shared
0.00
None
0.00
KALVISTA PHARMACEUTICALS INC
SOLEShares4.89M
TypeSH
Market value$55.26M
2.21%
Sole
4.89M
Shared
0.00
None
0.00
ZAI LAB LTD
SOLEShares1.31M
TypeSH
Market value$45.75M
1.83%
Sole
1.31M
Shared
0.00
None
0.00
AGIOS PHARMACEUTICALS INC
SOLEShares1.28M
TypeSH
Market value$42.56M
1.70%
Sole
1.28M
Shared
0.00
None
0.00
REVOLUTION MEDICINES INC
SOLEShares997.46K
TypeSH
Market value$36.70M
1.47%
Sole
997.46K
Shared
0.00
None
0.00
ULTRAGENYX PHARMACEUTICAL IN
SOLEShares983.72K
TypeSH
Market value$35.77M
1.43%
Sole
983.72K
Shared
0.00
None
0.00
AURA BIOSCIENCES INC
SOLEShares5.10M
TypeSH
Market value$31.93M
1.28%
Sole
5.10M
Shared
0.00
None
0.00
ERASCA INC
SOLEShares22.73M
TypeSH
Market value$28.87M
1.15%
Sole
22.73M
Shared
0.00
None
0.00
ALKERMES PLC
SOLEShares1M
TypeSH
Market value$28.63M
1.14%
Sole
1M
Shared
0.00
None
0.00
SAVARA INC
SOLEShares11.46M
TypeSH
Market value$26.13M
1.05%
Sole
11.46M
Shared
0.00
None
0.00
MEREO BIOPHARMA GROUP PLC
SOLEShares9.44M
TypeSH
Market value$25.58M
1.02%
Sole
9.44M
Shared
0.00
None
0.00
ASCENDIS PHARMA A/S
SOLEShares133.33K
TypeSH
Market value$23.01M
0.92%
Sole
133.33K
Shared
0.00
None
0.00
EVOLUS INC
SOLEShares2.44M
TypeSH
Market value$22.43M
0.90%
Sole
2.44M
Shared
0.00
None
0.00
HILLEVAX INC
SOLEShares10.62M
TypeSH
Market value$21.13M
0.84%
Sole
10.62M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
MIRUM PHARMACEUTICALS INCSOLE | COM | 6.80M | SH | $345.80M 13.83% | 6.80M | 0.00 | 0.00 |
VERONA PHARMA PLCSOLE | SPONSORED ADS | 3.38M | SH | $320.05M 12.80% | 3.38M | 0.00 | 0.00 |
NEWAMSTERDAM PHARMA COMPANYSOLE | ORDINARY SHARES | 16.61M | SH | $300.75M 12.03% | 16.61M | 0.00 | 0.00 |
BRIDGEBIO PHARMA INCSOLE | COM | 3.80M | SH | $164.10M 6.56% | 3.80M | 0.00 | 0.00 |
ARCUTIS BIOTHERAPEUTICS INCSOLE | COM | 9.87M | SH | $138.44M 5.54% | 9.87M | 0.00 | 0.00 |
PHATHOM PHARMACEUTICALS INCSOLE | COM | 12.47M | SH | $119.55M 4.78% | 12.47M | 0.00 | 0.00 |
KRYSTAL BIOTECH INCSOLE | COM | 688.46K | SH | $94.64M 3.78% | 688.46K | 0.00 | 0.00 |
DISC MEDICINE INCSOLE | COM | 1.65M | SH | $87.64M 3.50% | 1.65M | 0.00 | 0.00 |
MBX BIOSCIENCES INCSOLE | COM | 5.99M | SH | $68.29M 2.73% | 5.99M | 0.00 | 0.00 |
TARSUS PHARMACEUTICALS INCSOLE | COM | 1.40M | SH | $56.61M 2.26% | 1.40M | 0.00 | 0.00 |
TREVI THERAPEUTICS INCSOLE | COM | 10.26M | SH | $56.12M 2.24% | 10.26M | 0.00 | 0.00 |
MAZE THERAPEUTICS INCSOLE | COM | 4.57M | SH | $56.04M 2.24% | 4.57M | 0.00 | 0.00 |
KALVISTA PHARMACEUTICALS INCSOLE | COM | 4.89M | SH | $55.26M 2.21% | 4.89M | 0.00 | 0.00 |
ZAI LAB LTDSOLE | ADR | 1.31M | SH | $45.75M 1.83% | 1.31M | 0.00 | 0.00 |
AGIOS PHARMACEUTICALS INCSOLE | COM | 1.28M | SH | $42.56M 1.70% | 1.28M | 0.00 | 0.00 |
REVOLUTION MEDICINES INCSOLE | COM | 997.46K | SH | $36.70M 1.47% | 997.46K | 0.00 | 0.00 |
ULTRAGENYX PHARMACEUTICAL INSOLE | COM | 983.72K | SH | $35.77M 1.43% | 983.72K | 0.00 | 0.00 |
AURA BIOSCIENCES INCSOLE | COM | 5.10M | SH | $31.93M 1.28% | 5.10M | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 22.73M | SH | $28.87M 1.15% | 22.73M | 0.00 | 0.00 |
ALKERMES PLCSOLE | SHS | 1M | SH | $28.63M 1.14% | 1M | 0.00 | 0.00 |
SAVARA INCSOLE | COM | 11.46M | SH | $26.13M 1.05% | 11.46M | 0.00 | 0.00 |
MEREO BIOPHARMA GROUP PLCSOLE | SPON ADS | 9.44M | SH | $25.58M 1.02% | 9.44M | 0.00 | 0.00 |
ASCENDIS PHARMA A/SSOLE | SPONSORED ADR | 133.33K | SH | $23.01M 0.92% | 133.33K | 0.00 | 0.00 |
EVOLUS INCSOLE | COM | 2.44M | SH | $22.43M 0.90% | 2.44M | 0.00 | 0.00 |
HILLEVAX INCSOLE | COM | 10.62M | SH | $21.13M 0.84% | 10.62M | 0.00 | 0.00 |
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