CLOONAN MICHAEL (President & CEO) sold 15.4% of their position (99.80K shares) of SIONNA THERAPEUTICS, INC. on the open market

Open‑market sale worth $3.62M — a significant reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 4 sales

CLOONAN MICHAEL

Filed: 10/22/2025ACC: 0001704336-25-000008

InsiderCLOONAN MICHAELCIK 1704336

→

IssuerSIONNA THERAPEUTICS, INC.CIK 2036042

DirectorOfficer· President & CEO

Since Feb 2025

-99.80K

Net shares

Net seller

$3.62M

Total sold

Open market trades

0B · 4S

Total transactions

99.80K acquired · 199.60K disposed

Non-Derivative Transactions8

Common Stock

Direct

M · Option Exercise

+13.32K

Price / share

$6.11

Trade value

$81.41K

% of position

2.4%

10/21/2025

547.34K→560.67K

Common Stock

Direct

S · Sale

−13.32K

Price / share

$34.44

Trade value

$458.88K

% of position

2.4%

10/21/2025

560.67K→547.34K

Common Stock

Direct

M · Option Exercise

+30.05K

Price / share

$6.11

Trade value

$183.60K

% of position

5.5%

10/21/2025

547.34K→577.39K

Common Stock

Direct

S · Sale

−30.05K

Price / share

$35.63

Trade value

$1.07M

% of position

5.2%

10/21/2025

577.39K→547.34K

Common Stock

Direct

M · Option Exercise

+22.89K

Price / share

$6.11

Trade value

$139.89K

% of position

4.2%

10/21/2025

547.34K→570.24K

Common Stock

Direct

S · Sale

−22.89K

Price / share

$36.60

Trade value

$837.96K

% of position

4.0%

10/21/2025

570.24K→547.34K

Common Stock

Direct

M · Option Exercise

+33.53K

Price / share

$6.11

Trade value

$204.88K

% of position

6.1%

10/21/2025

547.34K→580.88K

Common Stock

Direct

S · Sale

−33.53K

Price / share

$37.31

Trade value

$1.25M

% of position

5.8%

10/21/2025

580.88K→547.34K

Total

Net shares

+0.00

Net value

-$3.01M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	10/21/2025	M · Option Exercise	+13.32K	$6.11	$81.41K	2.4%	547.34K	560.67K
Common Stock Direct	10/21/2025	S · Sale	−13.32K	$34.44	$458.88K	2.4%	560.67K	547.34K
Common Stock Direct	10/21/2025	M · Option Exercise	+30.05K	$6.11	$183.60K	5.5%	547.34K	577.39K
Common Stock Direct	10/21/2025	S · Sale	−30.05K	$35.63	$1.07M	5.2%	577.39K	547.34K
Common Stock Direct	10/21/2025	M · Option Exercise	+22.89K	$6.11	$139.89K	4.2%	547.34K	570.24K
Common Stock Direct	10/21/2025	S · Sale	−22.89K	$36.60	$837.96K	4.0%	570.24K	547.34K
Common Stock Direct	10/21/2025	M · Option Exercise	+33.53K	$6.11	$204.88K	6.1%	547.34K	580.88K
Common Stock Direct	10/21/2025	S · Sale	−33.53K	$37.31	$1.25M	5.8%	580.88K	547.34K
Total			+0.00		-$3.01M

Derivative Transactions4

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

13.32K shares

−13.32K

Strike price

6.11

Held after

139.62K

Exercisable

—

10/21/2025

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

30.05K shares

−30.05K

Strike price

6.11

Held after

109.57K

Exercisable

—

10/21/2025

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

22.89K shares

−22.89K

Strike price

6.11

Held after

86.67K

Exercisable

—

10/21/2025

Non-Qualified Stock Option (right to buy)

Direct

M · Option Exercise

Converts to

Common Stock

33.53K shares

−33.53K

Strike price

6.11

Held after

53.14K

Exercisable

—

10/21/2025

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Non-Qualified Stock Option (right to buy) Direct	Common Stock13.32K shares	10/21/2025	M · Option Exercise	−13.32K	6.11	—	139.62K
Non-Qualified Stock Option (right to buy) Direct	Common Stock30.05K shares	10/21/2025	M · Option Exercise	−30.05K	6.11	—	109.57K
Non-Qualified Stock Option (right to buy) Direct	Common Stock22.89K shares	10/21/2025	M · Option Exercise	−22.89K	6.11	—	86.67K
Non-Qualified Stock Option (right to buy) Direct	Common Stock33.53K shares	10/21/2025	M · Option Exercise	−33.53K	6.11	—	53.14K