CASTELLI JEFF (Chief Development Officer) reported 1 transaction at AMICUS THERAPEUTICS, INC.

Review the transaction codes below to understand the nature of each event.

CASTELLI JEFF

Filed: 4/27/2026ACC: 0001193125-26-182257

InsiderCASTELLI JEFFCIK 1569225

→

IssuerAMICUS THERAPEUTICS, INC.CIK 1178879

Officer· Chief Development Officer

Since Dec 2022

-1.10M

Net shares

Net seller

$6.19M

Total sold

Open market trades

0B · 0S

Total transactions

1.10M disposed

Non-Derivative Transactions1

Common Stock

Direct

D · Disposition

−427.09K

Price / share

$14.50

Trade value

$6.19M

% of position

New position

4/27/2026

427.09K→0.00

Total

Net shares

−427.09K

Net value

-$6.19M

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common Stock Direct	4/27/2026	D · Disposition	−427.09K	$14.50	$6.19M	New position	427.09K	0.00
Total			−427.09K		-$6.19M

Derivative Transactions6

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

82.64K shares

−82.64K

Strike price

10.04

Held after

0.00

Exercisable

—

4/27/2026

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

107.58K shares

−107.58K

Strike price

9.55

Held after

0.00

Exercisable

—

4/27/2026

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

108.27K shares

−108.27K

Strike price

12.11

Held after

0.00

Exercisable

—

4/27/2026

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

125.46K shares

−125.46K

Strike price

11.93

Held after

0.00

Exercisable

—

4/27/2026

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

99.07K shares

−99.07K

Strike price

14.24

Held after

0.00

Exercisable

—

4/27/2026

Stock Options (right to buy)

Direct

D · Disposition

Converts to

Common Stock

150.52K shares

−150.52K

Strike price

9.41

Held after

0.00

Exercisable

—

4/27/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable
Stock Options (right to buy) Direct	Common Stock82.64K shares	4/27/2026	D · Disposition	−82.64K	10.04	—
Stock Options (right to buy) Direct	Common Stock107.58K shares	4/27/2026	D · Disposition	−107.58K	9.55	—
Stock Options (right to buy) Direct	Common Stock108.27K shares	4/27/2026	D · Disposition	−108.27K	12.11	—
Stock Options (right to buy) Direct	Common Stock125.46K shares	4/27/2026	D · Disposition	−125.46K	11.93	—
Stock Options (right to buy) Direct	Common Stock99.07K shares	4/27/2026	D · Disposition	−99.07K	14.24	—
Stock Options (right to buy) Direct	Common Stock150.52K shares	4/27/2026	D · Disposition	−150.52K	9.41	—