BURNS JAMES WILLIAM (Chief Legal Officer) sold 10.6% of their position (5.22K shares) of AGIOS PHARMACEUTICALS, INC. on the open market

Open‑market sale worth $151.1K — a moderate reduction. Review remaining holdings and any 10b5‑1 plan disclosures.

S · 4 sales

BURNS JAMES WILLIAM

Filed: 3/3/2026ACC: 0001439222-26-000042

InsiderBURNS JAMES WILLIAMCIK 1900772

→

IssuerAGIOS PHARMACEUTICALS, INC.CIK 1439222

Officer· Chief Legal Officer

Since Jan 2022

+60.78K

Net shares

Net buyer

$151.1K

Total sold

Open market trades

0B · 4S

Total transactions

83.59K acquired · 22.80K disposed

Non-Derivative Transactions8

Common stock

Direct

M · Option Exercise

+4K

Price / share

—

Trade value

—

% of position

12.6%

3/2/2026

31.72K→35.72K

Common stock

Direct

S · Sale

−1.19K

Price / share

$28.96

Trade value

$34.38K

% of position

3.3%

3/2/2026

35.72K→34.53K

Common stock

Direct

M · Option Exercise

+5.67K

Price / share

—

Trade value

—

% of position

16.4%

3/2/2026

34.53K→40.20K

Common stock

Direct

S · Sale

−1.68K

Price / share

$28.96

Trade value

$48.68K

% of position

4.2%

3/2/2026

40.20K→38.52K

Common stock

Direct

M · Option Exercise

+4K

Price / share

—

Trade value

—

% of position

10.4%

3/2/2026

38.52K→42.52K

Common stock

Direct

S · Sale

−1.19K

Price / share

$28.96

Trade value

$34.38K

% of position

2.8%

3/2/2026

42.52K→41.33K

Common stock

Direct

M · Option Exercise

+3.92K

Price / share

—

Trade value

—

% of position

9.5%

3/2/2026

41.33K→45.25K

Common stock

Direct

S · Sale

−1.16K

Price / share

$28.96

Trade value

$33.68K

% of position

2.6%

3/2/2026

45.25K→44.09K

Total

Net shares

+12.37K

Net value

-$151.11K

Security	Date	Type	Shares	Price / Share	Trade Value	% of Position	Held Before	Held After
Common stock Direct	3/2/2026	M · Option Exercise	+4K	—	—	12.6%	31.72K	35.72K
Common stock Direct	3/2/2026	S · Sale	−1.19K	$28.96	$34.38K	3.3%	35.72K	34.53K
Common stock Direct	3/2/2026	M · Option Exercise	+5.67K	—	—	16.4%	34.53K	40.20K
Common stock Direct	3/2/2026	S · Sale	−1.68K	$28.96	$48.68K	4.2%	40.20K	38.52K
Common stock Direct	3/2/2026	M · Option Exercise	+4K	—	—	10.4%	38.52K	42.52K
Common stock Direct	3/2/2026	S · Sale	−1.19K	$28.96	$34.38K	2.8%	42.52K	41.33K
Common stock Direct	3/2/2026	M · Option Exercise	+3.92K	—	—	9.5%	41.33K	45.25K
Common stock Direct	3/2/2026	S · Sale	−1.16K	$28.96	$33.68K	2.6%	45.25K	44.09K
Total			+12.37K		-$151.11K

Derivative Transactions6

Restricted stock units

Direct

A · Award

Converts to

Common stock

14K shares

+14K

Strike price

Held after

14K

Exercisable

—

3/1/2026

Stock options (right to buy)

Direct

A · Award

Converts to

Common stock

52K shares

+52K

Strike price

30.23

Held after

52K

Exercisable

—

3/1/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

4K shares

−4K

Strike price

Held after

0.00

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

5.67K shares

−5.67K

Strike price

Held after

5.67K

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

4K shares

−4K

Strike price

Held after

Exercisable

—

3/2/2026

Restricted stock units

Direct

M · Option Exercise

Converts to

Common stock

3.92K shares

−3.92K

Strike price

Held after

7.84K

Exercisable

—

3/2/2026

Security	Converts To	Date	Type	Shares	Strike Price	Exercisable	Held After
Restricted stock units Direct	Common stock14K shares	3/1/2026	A · Award	+14K		—	14K
Stock options (right to buy) Direct	Common stock52K shares	3/1/2026	A · Award	+52K	30.23	—	52K
Restricted stock units Direct	Common stock4K shares	3/2/2026	M · Option Exercise	−4K		—	0.00
Restricted stock units Direct	Common stock5.67K shares	3/2/2026	M · Option Exercise	−5.67K		—	5.67K
Restricted stock units Direct	Common stock4K shares	3/2/2026	M · Option Exercise	−4K		—	8K
Restricted stock units Direct	Common stock3.92K shares	3/2/2026	M · Option Exercise	−3.92K		—	7.84K