Filed: 8/14/2025ACC: 0001104659-25-078573
📋 What this filing means
BAKER BROS. ADVISORS LP filed this quarterly 13F‑HR report disclosing 89 equity positions with a total reported market value of $10.31B. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
89
Positions
$10.31B
Total AUM (reported)
372.13M
Total Shares
Allocation by class
COM$6.70B65.0%
SPONSORED ADS$2.33B22.6%
COM PAR $.01$776.23M7.5%
SHS$282.82M2.7%
ORD SHS CL A$78.16M0.8%
ADS$72.88M0.7%
SPONSORED ADR$20.81M0.2%
Portfolio Concentration
Top 3$5.15B50.0%
4–10$3.26B31.7%
11–25$1.14B11.1%
Rest$754.39M7.3%
Top 3 weight
50.0%
Top 10 weight
81.6%
Voting Authority Distribution
Total shares with voting rights: 372.13M
Sole
Full voting authority
372.13M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole89
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings89
Rows:
BeOne Medicines Ltd.
SOLEShares8.80M
TypeSH
Market value$2.13B
20.66%
Sole
8.80M
Shared
0.00
None
0.00
Incyte Corporation
SOLEShares30.74M
TypeSH
Market value$2.09B
20.31%
Sole
30.74M
Shared
0.00
None
0.00
ACADIA Pharmaceuticals Inc.
SOLEShares42.90M
TypeSH
Market value$925.28M
8.98%
Sole
42.90M
Shared
0.00
None
0.00
Insmed Incorporated
SOLEShares7.71M
TypeSH
Market value$776.23M
7.53%
Sole
7.71M
Shared
0.00
None
0.00
Summit Therapeutics Inc.
SOLEShares33.72M
TypeSH
Market value$717.62M
6.96%
Sole
33.72M
Shared
0.00
None
0.00
Madrigal Pharmaceuticals, Inc.
SOLEShares1.98M
TypeSH
Market value$598.02M
5.80%
Sole
1.98M
Shared
0.00
None
0.00
Rhythm Pharmaceuticals, Inc.
SOLEShares5.60M
TypeSH
Market value$354.15M
3.44%
Sole
5.60M
Shared
0.00
None
0.00
Revolution Medicines, Inc.
SOLEShares9.36M
TypeSH
Market value$344.54M
3.34%
Sole
9.36M
Shared
0.00
None
0.00
Kymera Therapeutics, Inc.
SOLEShares6.65M
TypeSH
Market value$290.27M
2.82%
Sole
6.65M
Shared
0.00
None
0.00
Alkermes plc
SOLEShares6.41M
TypeSH
Market value$183.41M
1.78%
Sole
6.41M
Shared
0.00
None
0.00
Replimune Group, Inc.
SOLEShares11.05M
TypeSH
Market value$102.61M
1.00%
Sole
11.05M
Shared
0.00
None
0.00
Ultragenyx Pharmaceutical Inc.
SOLEShares2.77M
TypeSH
Market value$100.82M
0.98%
Sole
2.77M
Shared
0.00
None
0.00
Edgewise Therapeutics, Inc.
SOLEShares7.31M
TypeSH
Market value$95.78M
0.93%
Sole
7.31M
Shared
0.00
None
0.00
AbCellera Biologics Inc.
SOLEShares27.53M
TypeSH
Market value$94.41M
0.92%
Sole
27.53M
Shared
0.00
None
0.00
Immunovant, Inc.
SOLEShares5.46M
TypeSH
Market value$87.33M
0.85%
Sole
5.46M
Shared
0.00
None
0.00
GRAIL, Inc.
SOLEShares1.63M
TypeSH
Market value$83.82M
0.81%
Sole
1.63M
Shared
0.00
None
0.00
Kiniksa Pharmaceuticals International, plc
SOLEShares2.82M
TypeSH
Market value$78.16M
0.76%
Sole
2.82M
Shared
0.00
None
0.00
Bicycle Therapeutics plc
SOLEShares10.89M
TypeSH
Market value$75.65M
0.73%
Sole
10.89M
Shared
0.00
None
0.00
Immunocore Holdings plc
SOLEShares2.32M
TypeSH
Market value$72.88M
0.71%
Sole
2.32M
Shared
0.00
None
0.00
Celcuity Inc.
SOLEShares5.45M
TypeSH
Market value$72.76M
0.71%
Sole
5.45M
Shared
0.00
None
0.00
Kodiak Sciences Inc.
SOLEShares17.31M
TypeSH
Market value$64.57M
0.63%
Sole
17.31M
Shared
0.00
None
0.00
Immatics N.V.
SOLEShares10.17M
TypeSH
Market value$54.71M
0.53%
Sole
10.17M
Shared
0.00
None
0.00
Stoke Therapeutics, Inc.
SOLEShares4.63M
TypeSH
Market value$52.59M
0.51%
Sole
4.63M
Shared
0.00
None
0.00
Denali Therapeutics Inc.
SOLEShares3.73M
TypeSH
Market value$52.21M
0.51%
Sole
3.73M
Shared
0.00
None
0.00
Structure Therapeutics Inc.
SOLEShares2.51M
TypeSH
Market value$52.03M
0.50%
Sole
2.51M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
BeOne Medicines Ltd.SOLE | SPONSORED ADS | 8.80M | SH | $2.13B 20.66% | 8.80M | 0.00 | 0.00 |
Incyte CorporationSOLE | COM | 30.74M | SH | $2.09B 20.31% | 30.74M | 0.00 | 0.00 |
ACADIA Pharmaceuticals Inc.SOLE | COM | 42.90M | SH | $925.28M 8.98% | 42.90M | 0.00 | 0.00 |
Insmed IncorporatedSOLE | COM PAR $.01 | 7.71M | SH | $776.23M 7.53% | 7.71M | 0.00 | 0.00 |
Summit Therapeutics Inc.SOLE | COM | 33.72M | SH | $717.62M 6.96% | 33.72M | 0.00 | 0.00 |
Madrigal Pharmaceuticals, Inc.SOLE | COM | 1.98M | SH | $598.02M 5.80% | 1.98M | 0.00 | 0.00 |
Rhythm Pharmaceuticals, Inc.SOLE | COM | 5.60M | SH | $354.15M 3.44% | 5.60M | 0.00 | 0.00 |
Revolution Medicines, Inc.SOLE | COM | 9.36M | SH | $344.54M 3.34% | 9.36M | 0.00 | 0.00 |
Kymera Therapeutics, Inc.SOLE | COM | 6.65M | SH | $290.27M 2.82% | 6.65M | 0.00 | 0.00 |
Alkermes plcSOLE | SHS | 6.41M | SH | $183.41M 1.78% | 6.41M | 0.00 | 0.00 |
Replimune Group, Inc.SOLE | COM | 11.05M | SH | $102.61M 1.00% | 11.05M | 0.00 | 0.00 |
Ultragenyx Pharmaceutical Inc.SOLE | COM | 2.77M | SH | $100.82M 0.98% | 2.77M | 0.00 | 0.00 |
Edgewise Therapeutics, Inc.SOLE | COM | 7.31M | SH | $95.78M 0.93% | 7.31M | 0.00 | 0.00 |
AbCellera Biologics Inc.SOLE | COM | 27.53M | SH | $94.41M 0.92% | 27.53M | 0.00 | 0.00 |
Immunovant, Inc.SOLE | COM | 5.46M | SH | $87.33M 0.85% | 5.46M | 0.00 | 0.00 |
GRAIL, Inc.SOLE | COM | 1.63M | SH | $83.82M 0.81% | 1.63M | 0.00 | 0.00 |
Kiniksa Pharmaceuticals International, plcSOLE | ORD SHS CL A | 2.82M | SH | $78.16M 0.76% | 2.82M | 0.00 | 0.00 |
Bicycle Therapeutics plcSOLE | SPONSORED ADS | 10.89M | SH | $75.65M 0.73% | 10.89M | 0.00 | 0.00 |
Immunocore Holdings plcSOLE | ADS | 2.32M | SH | $72.88M 0.71% | 2.32M | 0.00 | 0.00 |
Celcuity Inc.SOLE | COM | 5.45M | SH | $72.76M 0.71% | 5.45M | 0.00 | 0.00 |
Kodiak Sciences Inc.SOLE | COM | 17.31M | SH | $64.57M 0.63% | 17.31M | 0.00 | 0.00 |
Immatics N.V.SOLE | SHS | 10.17M | SH | $54.71M 0.53% | 10.17M | 0.00 | 0.00 |
Stoke Therapeutics, Inc.SOLE | COM | 4.63M | SH | $52.59M 0.51% | 4.63M | 0.00 | 0.00 |
Denali Therapeutics Inc.SOLE | COM | 3.73M | SH | $52.21M 0.51% | 3.73M | 0.00 | 0.00 |
Structure Therapeutics Inc.SOLE | SPONSORED ADS | 2.51M | SH | $52.03M 0.50% | 2.51M | 0.00 | 0.00 |
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