Filed: 2/17/2026ACC: 0001799883-26-000001
📋 What this filing means
5AM VENTURE MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 21 equity positions with a total reported market value of $318.10M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
21
Positions
$318.10M
Total AUM (reported)
45.51M
Total Shares
Allocation by class
COM$237.40M74.6%
COM NEW$48.71M15.3%
SPONSORED ADS$14.53M4.6%
COM STK$7.30M2.3%
ORDINARY SHARES$7.27M2.3%
ADS$2.90M0.9%
Portfolio Concentration
Top 3$104.74M32.9%
4–10$129.07M40.6%
11–25$84.30M26.5%
Top 3 weight
32.9%
Top 10 weight
73.5%
Voting Authority Distribution
Total shares with voting rights: 45.51M
Sole
Full voting authority
45.51M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole21
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings21
Rows:
ENTRADA THERAPEUTICS INC
SOLEShares4.06M
TypeSH
Market value$41.70M
13.11%
Sole
4.06M
Shared
0.00
None
0.00
CAMP4 THERAPEUTICS CORP
SOLEShares5.87M
TypeSH
Market value$35.98M
11.31%
Sole
5.87M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares1.03M
TypeSH
Market value$27.06M
8.51%
Sole
1.03M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares736.60K
TypeSH
Market value$22.92M
7.21%
Sole
736.60K
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares797.60K
TypeSH
Market value$22.13M
6.96%
Sole
797.60K
Shared
0.00
None
0.00
ERASCA INC
SOLEShares5.41M
TypeSH
Market value$20.11M
6.32%
Sole
5.41M
Shared
0.00
None
0.00
EYEPOINT INC
SOLEShares1.05M
TypeSH
Market value$19.18M
6.03%
Sole
1.05M
Shared
0.00
None
0.00
MAPLIGHT THERAPEUTICS INC
SOLEShares950.01K
TypeSH
Market value$16.69M
5.25%
Sole
950.01K
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares580.95K
TypeSH
Market value$14.53M
4.57%
Sole
580.95K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
SOLEShares497.27K
TypeSH
Market value$13.51M
4.25%
Sole
497.27K
Shared
0.00
None
0.00
TECTONIC THERAPEUTIC INC
SOLEShares606.66K
TypeSH
Market value$12.65M
3.98%
Sole
606.66K
Shared
0.00
None
0.00
ENLIVEN THERAPEUTICS INC
SOLEShares772.48K
TypeSH
Market value$11.90M
3.74%
Sole
772.48K
Shared
0.00
None
0.00
ARTIVA BIOTHERAPEUTICS INC
SOLEShares2.35M
TypeSH
Market value$10.10M
3.17%
Sole
2.35M
Shared
0.00
None
0.00
SURROZEN INC
SOLEShares387.50K
TypeSH
Market value$8.76M
2.75%
Sole
387.50K
Shared
0.00
None
0.00
BIOHAVEN LTD
SOLEShares738.97K
TypeSH
Market value$8.34M
2.62%
Sole
738.97K
Shared
0.00
None
0.00
PROTARA THERAPEUTICS INC
SOLEShares1.37M
TypeSH
Market value$7.30M
2.30%
Sole
1.37M
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares572.66K
TypeSH
Market value$7.27M
2.29%
Sole
572.66K
Shared
0.00
None
0.00
SKYE BIOSCIENCE INC
SOLEShares9.68M
TypeSH
Market value$7.26M
2.28%
Sole
9.68M
Shared
0.00
None
0.00
ZENTALIS PHARMACEUTICALS INC
SOLEShares3.95M
TypeSH
Market value$5.33M
1.68%
Sole
3.95M
Shared
0.00
None
0.00
SILENCE THERAPEUTICS PLC
SOLEShares476.20K
TypeSH
Market value$2.90M
0.91%
Sole
476.20K
Shared
0.00
None
0.00
RALLYBIO CORP
SOLEShares3.63M
TypeSH
Market value$2.49M
0.78%
Sole
3.63M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ENTRADA THERAPEUTICS INCSOLE | COM | 4.06M | SH | $41.70M 13.11% | 4.06M | 0.00 | 0.00 |
CAMP4 THERAPEUTICS CORPSOLE | COM | 5.87M | SH | $35.98M 11.31% | 5.87M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COM | 1.03M | SH | $27.06M 8.51% | 1.03M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 736.60K | SH | $22.92M 7.21% | 736.60K | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 797.60K | SH | $22.13M 6.96% | 797.60K | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 5.41M | SH | $20.11M 6.32% | 5.41M | 0.00 | 0.00 |
EYEPOINT INCSOLE | COM NEW | 1.05M | SH | $19.18M 6.03% | 1.05M | 0.00 | 0.00 |
MAPLIGHT THERAPEUTICS INCSOLE | COM | 950.01K | SH | $16.69M 5.25% | 950.01K | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 580.95K | SH | $14.53M 4.57% | 580.95K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWSOLE | COM NEW | 497.27K | SH | $13.51M 4.25% | 497.27K | 0.00 | 0.00 |
TECTONIC THERAPEUTIC INCSOLE | COM | 606.66K | SH | $12.65M 3.98% | 606.66K | 0.00 | 0.00 |
ENLIVEN THERAPEUTICS INCSOLE | COM | 772.48K | SH | $11.90M 3.74% | 772.48K | 0.00 | 0.00 |
ARTIVA BIOTHERAPEUTICS INCSOLE | COM | 2.35M | SH | $10.10M 3.17% | 2.35M | 0.00 | 0.00 |
SURROZEN INCSOLE | COM NEW | 387.50K | SH | $8.76M 2.75% | 387.50K | 0.00 | 0.00 |
BIOHAVEN LTDSOLE | COM | 738.97K | SH | $8.34M 2.62% | 738.97K | 0.00 | 0.00 |
PROTARA THERAPEUTICS INCSOLE | COM STK | 1.37M | SH | $7.30M 2.30% | 1.37M | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | ORDINARY SHARES | 572.66K | SH | $7.27M 2.29% | 572.66K | 0.00 | 0.00 |
SKYE BIOSCIENCE INCSOLE | COM NEW | 9.68M | SH | $7.26M 2.28% | 9.68M | 0.00 | 0.00 |
ZENTALIS PHARMACEUTICALS INCSOLE | COM | 3.95M | SH | $5.33M 1.68% | 3.95M | 0.00 | 0.00 |
SILENCE THERAPEUTICS PLCSOLE | ADS | 476.20K | SH | $2.90M 0.91% | 476.20K | 0.00 | 0.00 |
RALLYBIO CORPSOLE | COM | 3.63M | SH | $2.49M 0.78% | 3.63M | 0.00 | 0.00 |