Filed: 11/14/2025ACC: 0001799883-25-000002
📋 What this filing means
5AM VENTURE MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 25 equity positions with a total reported market value of $273.05M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
25
Positions
$273.05M
Total AUM (reported)
42.44M
Total Shares
Allocation by class
COM$161.07M59.0%
COM NEW$81.32M29.8%
SPONSORED ADS$16.51M6.0%
ORDINARY SHARES$8.19M3.0%
COM STK$3.48M1.3%
ADS$2.47M0.9%
Portfolio Concentration
Top 3$82.64M30.3%
4–10$108.29M39.7%
11–25$82.12M30.1%
Top 3 weight
30.3%
Top 10 weight
69.9%
Voting Authority Distribution
Total shares with voting rights: 42.44M
Sole
Full voting authority
42.44M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole25
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings25
Rows:
SKYE BIOSCIENCE INC
SOLEShares9.68M
TypeSH
Market value$38.05M
13.94%
Sole
9.68M
Shared
0.00
None
0.00
ENTRADA THERAPEUTICS INC
SOLEShares4.26M
TypeSH
Market value$24.69M
9.04%
Sole
4.26M
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares797.60K
TypeSH
Market value$19.90M
7.29%
Sole
797.60K
Shared
0.00
None
0.00
CAMP4 THERAPEUTICS CORP
SOLEShares5.87M
TypeSH
Market value$17.61M
6.45%
Sole
5.87M
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares680.95K
TypeSH
Market value$16.51M
6.05%
Sole
680.95K
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares736.60K
TypeSH
Market value$15.90M
5.82%
Sole
736.60K
Shared
0.00
None
0.00
ENLIVEN THERAPEUTICS INC
SOLEShares772.48K
TypeSH
Market value$15.81M
5.79%
Sole
772.48K
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares1.05M
TypeSH
Market value$14.95M
5.48%
Sole
1.05M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares365.05K
TypeSH
Market value$14.36M
5.26%
Sole
365.05K
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares939.30K
TypeSH
Market value$13.14M
4.81%
Sole
939.30K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
SOLEShares497.27K
TypeSH
Market value$12.86M
4.71%
Sole
497.27K
Shared
0.00
None
0.00
ERASCA INC
SOLEShares5.41M
TypeSH
Market value$11.78M
4.32%
Sole
5.41M
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares170K
TypeSH
Market value$9.01M
3.30%
Sole
170K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares572.66K
TypeSH
Market value$8.19M
3.00%
Sole
572.66K
Shared
0.00
None
0.00
TECTONIC THERAPEUTIC INC
SOLEShares511.66K
TypeSH
Market value$8.03M
2.94%
Sole
511.66K
Shared
0.00
None
0.00
BIOHAVEN LTD
SOLEShares478.97K
TypeSH
Market value$7.19M
2.63%
Sole
478.97K
Shared
0.00
None
0.00
ARTIVA BIOTHERAPEUTICS INC
SOLEShares2.35M
TypeSH
Market value$6.75M
2.47%
Sole
2.35M
Shared
0.00
None
0.00
SURROZEN INC
SOLEShares310K
TypeSH
Market value$3.99M
1.46%
Sole
310K
Shared
0.00
None
0.00
PROTARA THERAPEUTICS INC
SOLEShares800K
TypeSH
Market value$3.48M
1.27%
Sole
800K
Shared
0.00
None
0.00
ALECTOR INC
SOLEShares995.84K
TypeSH
Market value$2.95M
1.08%
Sole
995.84K
Shared
0.00
None
0.00
SILENCE THERAPEUTICS PLC
SOLEShares476.20K
TypeSH
Market value$2.47M
0.91%
Sole
476.20K
Shared
0.00
None
0.00
ADVERUM BIOTECHNOLOGIES INC
SOLEShares541.67K
TypeSH
Market value$2.45M
0.90%
Sole
541.67K
Shared
0.00
None
0.00
RALLYBIO CORP
SOLEShares3.63M
TypeSH
Market value$1.81M
0.66%
Sole
3.63M
Shared
0.00
None
0.00
ZENTALIS PHARMACEUTICALS INC
SOLEShares490K
TypeSH
Market value$739.9K
0.27%
Sole
490K
Shared
0.00
None
0.00
MERSANA THERAPEUTICS INC
SOLEShares52.20K
TypeSH
Market value$405.1K
0.15%
Sole
52.20K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
SKYE BIOSCIENCE INCSOLE | COM NEW | 9.68M | SH | $38.05M 13.94% | 9.68M | 0.00 | 0.00 |
ENTRADA THERAPEUTICS INCSOLE | COM | 4.26M | SH | $24.69M 9.04% | 4.26M | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 797.60K | SH | $19.90M 7.29% | 797.60K | 0.00 | 0.00 |
CAMP4 THERAPEUTICS CORPSOLE | COM | 5.87M | SH | $17.61M 6.45% | 5.87M | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 680.95K | SH | $16.51M 6.05% | 680.95K | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 736.60K | SH | $15.90M 5.82% | 736.60K | 0.00 | 0.00 |
ENLIVEN THERAPEUTICS INCSOLE | COM | 772.48K | SH | $15.81M 5.79% | 772.48K | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COM NEW | 1.05M | SH | $14.95M 5.48% | 1.05M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COM | 365.05K | SH | $14.36M 5.26% | 365.05K | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COM | 939.30K | SH | $13.14M 4.81% | 939.30K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWSOLE | COM NEW | 497.27K | SH | $12.86M 4.71% | 497.27K | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 5.41M | SH | $11.78M 4.32% | 5.41M | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 170K | SH | $9.01M 3.30% | 170K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | ORDINARY SHARES | 572.66K | SH | $8.19M 3.00% | 572.66K | 0.00 | 0.00 |
TECTONIC THERAPEUTIC INCSOLE | COM | 511.66K | SH | $8.03M 2.94% | 511.66K | 0.00 | 0.00 |
BIOHAVEN LTDSOLE | COM | 478.97K | SH | $7.19M 2.63% | 478.97K | 0.00 | 0.00 |
ARTIVA BIOTHERAPEUTICS INCSOLE | COM | 2.35M | SH | $6.75M 2.47% | 2.35M | 0.00 | 0.00 |
SURROZEN INCSOLE | COM NEW | 310K | SH | $3.99M 1.46% | 310K | 0.00 | 0.00 |
PROTARA THERAPEUTICS INCSOLE | COM STK | 800K | SH | $3.48M 1.27% | 800K | 0.00 | 0.00 |
ALECTOR INCSOLE | COM | 995.84K | SH | $2.95M 1.08% | 995.84K | 0.00 | 0.00 |
SILENCE THERAPEUTICS PLCSOLE | ADS | 476.20K | SH | $2.47M 0.91% | 476.20K | 0.00 | 0.00 |
ADVERUM BIOTECHNOLOGIES INCSOLE | COM NEW | 541.67K | SH | $2.45M 0.90% | 541.67K | 0.00 | 0.00 |
RALLYBIO CORPSOLE | COM | 3.63M | SH | $1.81M 0.66% | 3.63M | 0.00 | 0.00 |
ZENTALIS PHARMACEUTICALS INCSOLE | COM | 490K | SH | $739.9K 0.27% | 490K | 0.00 | 0.00 |
MERSANA THERAPEUTICS INCSOLE | COM | 52.20K | SH | $405.1K 0.15% | 52.20K | 0.00 | 0.00 |