Filed: 8/14/2025ACC: 0001085146-25-005241
📋 What this filing means
5AM VENTURE MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 29 equity positions with a total reported market value of $260.12M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
29
Positions
$260.12M
Total AUM (reported)
49.83M
Total Shares
Allocation by class
COM$151.19M58.1%
COM NEW$72.52M27.9%
CLASS A ORD$13.33M5.1%
SPONSORED ADS$10.92M4.2%
ORDINARY SHARES$6.98M2.7%
ADS$2.76M1.1%
COM STK$2.42M0.9%
Portfolio Concentration
Top 3$88.73M34.1%
4–10$84.55M32.5%
11–25$83.49M32.1%
Rest$3.35M1.3%
Top 3 weight
34.1%
Top 10 weight
66.6%
Voting Authority Distribution
Total shares with voting rights: 49.83M
Sole
Full voting authority
49.83M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole29
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings29
Rows:
SKYE BIOSCIENCE INC
SOLEShares9.91M
TypeSH
Market value$41.44M
15.93%
Sole
9.91M
Shared
0.00
None
0.00
ENTRADA THERAPEUTICS INC
SOLEShares4.31M
TypeSH
Market value$28.95M
11.13%
Sole
4.31M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares984.73K
TypeSH
Market value$18.35M
7.05%
Sole
984.73K
Shared
0.00
None
0.00
ENLIVEN THERAPEUTICS INC
SOLEShares772.48K
TypeSH
Market value$15.50M
5.96%
Sole
772.48K
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares797.60K
TypeSH
Market value$14.04M
5.40%
Sole
797.60K
Shared
0.00
None
0.00
MOONLAKE IMMUNOTHERAPEUTICS
SOLEShares282.31K
TypeSH
Market value$13.33M
5.12%
Sole
282.31K
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares830.95K
TypeSH
Market value$10.92M
4.20%
Sole
830.95K
Shared
0.00
None
0.00
VOR BIOPHARMA INC
SOLEShares6.36M
TypeSH
Market value$10.31M
3.96%
Sole
6.36M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares736.60K
TypeSH
Market value$10.30M
3.96%
Sole
736.60K
Shared
0.00
None
0.00
TECTONIC THERAPEUTIC INC
SOLEShares511.66K
TypeSH
Market value$10.17M
3.91%
Sole
511.66K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
SOLEShares497.27K
TypeSH
Market value$10.12M
3.89%
Sole
497.27K
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares1.05M
TypeSH
Market value$9.88M
3.80%
Sole
1.05M
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares939.30K
TypeSH
Market value$8.99M
3.46%
Sole
939.30K
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares170K
TypeSH
Market value$7.15M
2.75%
Sole
170K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares572.66K
TypeSH
Market value$6.98M
2.68%
Sole
572.66K
Shared
0.00
None
0.00
ERASCA INC
SOLEShares5.41M
TypeSH
Market value$6.86M
2.64%
Sole
5.41M
Shared
0.00
None
0.00
BIOHAVEN LTD
SOLEShares478.97K
TypeSH
Market value$6.76M
2.60%
Sole
478.97K
Shared
0.00
None
0.00
VIKING THERAPEUTICS INC
SOLEShares189.59K
TypeSH
Market value$5.02M
1.93%
Sole
189.59K
Shared
0.00
None
0.00
SCPHARMACEUTICALS INC
SOLEShares1.20M
TypeSH
Market value$4.57M
1.76%
Sole
1.20M
Shared
0.00
None
0.00
CAMP4 THERAPEUTICS CORP
SOLEShares2.93M
TypeSH
Market value$4.25M
1.63%
Sole
2.93M
Shared
0.00
None
0.00
ARTIVA BIOTHERAPEUTICS INC
SOLEShares2.35M
TypeSH
Market value$3.55M
1.37%
Sole
2.35M
Shared
0.00
None
0.00
SURROZEN INC
SOLEShares310K
TypeSH
Market value$2.77M
1.07%
Sole
310K
Shared
0.00
None
0.00
SILENCE THERAPEUTICS PLC
SOLEShares476.20K
TypeSH
Market value$2.76M
1.06%
Sole
476.20K
Shared
0.00
None
0.00
PROTARA THERAPEUTICS INC
SOLEShares800K
TypeSH
Market value$2.42M
0.93%
Sole
800K
Shared
0.00
None
0.00
ALECTOR INC
SOLEShares995.84K
TypeSH
Market value$1.39M
0.54%
Sole
995.84K
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
SKYE BIOSCIENCE INCSOLE | COM NEW | 9.91M | SH | $41.44M 15.93% | 9.91M | 0.00 | 0.00 |
ENTRADA THERAPEUTICS INCSOLE | COM | 4.31M | SH | $28.95M 11.13% | 4.31M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COM | 984.73K | SH | $18.35M 7.05% | 984.73K | 0.00 | 0.00 |
ENLIVEN THERAPEUTICS INCSOLE | COM | 772.48K | SH | $15.50M 5.96% | 772.48K | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 797.60K | SH | $14.04M 5.40% | 797.60K | 0.00 | 0.00 |
MOONLAKE IMMUNOTHERAPEUTICSSOLE | CLASS A ORD | 282.31K | SH | $13.33M 5.12% | 282.31K | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 830.95K | SH | $10.92M 4.20% | 830.95K | 0.00 | 0.00 |
VOR BIOPHARMA INCSOLE | COM | 6.36M | SH | $10.31M 3.96% | 6.36M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 736.60K | SH | $10.30M 3.96% | 736.60K | 0.00 | 0.00 |
TECTONIC THERAPEUTIC INCSOLE | COM | 511.66K | SH | $10.17M 3.91% | 511.66K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWSOLE | COM NEW | 497.27K | SH | $10.12M 3.89% | 497.27K | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COM NEW | 1.05M | SH | $9.88M 3.80% | 1.05M | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COM | 939.30K | SH | $8.99M 3.46% | 939.30K | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 170K | SH | $7.15M 2.75% | 170K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | ORDINARY SHARES | 572.66K | SH | $6.98M 2.68% | 572.66K | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 5.41M | SH | $6.86M 2.64% | 5.41M | 0.00 | 0.00 |
BIOHAVEN LTDSOLE | COM | 478.97K | SH | $6.76M 2.60% | 478.97K | 0.00 | 0.00 |
VIKING THERAPEUTICS INCSOLE | COM | 189.59K | SH | $5.02M 1.93% | 189.59K | 0.00 | 0.00 |
SCPHARMACEUTICALS INCSOLE | COM | 1.20M | SH | $4.57M 1.76% | 1.20M | 0.00 | 0.00 |
CAMP4 THERAPEUTICS CORPSOLE | COM | 2.93M | SH | $4.25M 1.63% | 2.93M | 0.00 | 0.00 |
ARTIVA BIOTHERAPEUTICS INCSOLE | COM | 2.35M | SH | $3.55M 1.37% | 2.35M | 0.00 | 0.00 |
SURROZEN INCSOLE | COM NEW | 310K | SH | $2.77M 1.07% | 310K | 0.00 | 0.00 |
SILENCE THERAPEUTICS PLCSOLE | ADS | 476.20K | SH | $2.76M 1.06% | 476.20K | 0.00 | 0.00 |
PROTARA THERAPEUTICS INCSOLE | COM STK | 800K | SH | $2.42M 0.93% | 800K | 0.00 | 0.00 |
ALECTOR INCSOLE | COM | 995.84K | SH | $1.39M 0.54% | 995.84K | 0.00 | 0.00 |
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