Filed: 5/15/2025ACC: 0001085146-25-003293
📋 What this filing means
5AM VENTURE MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 31 equity positions with a total reported market value of $264.41M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
31
Positions
$264.41M
Total AUM (reported)
50.94M
Total Shares
Allocation by class
COM$186.24M70.4%
COM NEW$44.12M16.7%
SPONSORED ADS$11.95M4.5%
CLASS A ORD$11.03M4.2%
ORDINARY SHARES$6.32M2.4%
COM STK$3.41M1.3%
ADS$1.34M0.5%
Portfolio Concentration
Top 3$84.52M32.0%
4–10$84.42M31.9%
11–25$88.08M33.3%
Rest$7.38M2.8%
Top 3 weight
32.0%
Top 10 weight
63.9%
Voting Authority Distribution
Total shares with voting rights: 50.94M
Sole
Full voting authority
50.94M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole31
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings31
Rows:
ENTRADA THERAPEUTICS INC
SOLEShares4.41M
TypeSH
Market value$39.85M
15.07%
Sole
4.41M
Shared
0.00
None
0.00
ENLIVEN THERAPEUTICS INC
SOLEShares1.32M
TypeSH
Market value$26.03M
9.84%
Sole
1.32M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares1.03M
TypeSH
Market value$18.64M
7.05%
Sole
1.03M
Shared
0.00
None
0.00
SKYE BIOSCIENCE INC
SOLEShares9.91M
TypeSH
Market value$15.76M
5.96%
Sole
9.91M
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares797.60K
TypeSH
Market value$12.52M
4.74%
Sole
797.60K
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares830.95K
TypeSH
Market value$11.95M
4.52%
Sole
830.95K
Shared
0.00
None
0.00
CAMP4 THERAPEUTICS CORP
SOLEShares2.93M
TypeSH
Market value$11.71M
4.43%
Sole
2.93M
Shared
0.00
None
0.00
BIOHAVEN LTD
SOLEShares478.97K
TypeSH
Market value$11.51M
4.35%
Sole
478.97K
Shared
0.00
None
0.00
MOONLAKE IMMUNOTHERAPEUTICS
SOLEShares282.31K
TypeSH
Market value$11.03M
4.17%
Sole
282.31K
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares736.60K
TypeSH
Market value$9.93M
3.76%
Sole
736.60K
Shared
0.00
None
0.00
TECTONIC THERAPEUTIC INC
SOLEShares511.66K
TypeSH
Market value$9.06M
3.43%
Sole
511.66K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
SOLEShares497.27K
TypeSH
Market value$9.03M
3.41%
Sole
497.27K
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares939.30K
TypeSH
Market value$8.74M
3.30%
Sole
939.30K
Shared
0.00
None
0.00
ERASCA INC
SOLEShares5.41M
TypeSH
Market value$7.41M
2.80%
Sole
5.41M
Shared
0.00
None
0.00
ARTIVA BIOTHERAPEUTICS INC
SOLEShares2.35M
TypeSH
Market value$7.06M
2.67%
Sole
2.35M
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares357.73K
TypeSH
Market value$6.65M
2.52%
Sole
357.73K
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares170K
TypeSH
Market value$6.44M
2.43%
Sole
170K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares572.66K
TypeSH
Market value$6.32M
2.39%
Sole
572.66K
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares1.05M
TypeSH
Market value$5.69M
2.15%
Sole
1.05M
Shared
0.00
None
0.00
VIKING THERAPEUTICS INC
SOLEShares189.59K
TypeSH
Market value$4.58M
1.73%
Sole
189.59K
Shared
0.00
None
0.00
VOR BIOPHARMA INC
SOLEShares6.36M
TypeSH
Market value$4.56M
1.73%
Sole
6.36M
Shared
0.00
None
0.00
SURROZEN INC
SOLEShares310K
TypeSH
Market value$3.61M
1.37%
Sole
310K
Shared
0.00
None
0.00
PROTARA THERAPEUTICS INC
SOLEShares800K
TypeSH
Market value$3.41M
1.29%
Sole
800K
Shared
0.00
None
0.00
SCPHARMACEUTICALS INC
SOLEShares1.20M
TypeSH
Market value$3.16M
1.19%
Sole
1.20M
Shared
0.00
None
0.00
RALLYBIO CORP
SOLEShares3.63M
TypeSH
Market value$2.38M
0.90%
Sole
3.63M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ENTRADA THERAPEUTICS INCSOLE | COM | 4.41M | SH | $39.85M 15.07% | 4.41M | 0.00 | 0.00 |
ENLIVEN THERAPEUTICS INCSOLE | COM | 1.32M | SH | $26.03M 9.84% | 1.32M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COM | 1.03M | SH | $18.64M 7.05% | 1.03M | 0.00 | 0.00 |
SKYE BIOSCIENCE INCSOLE | COM NEW | 9.91M | SH | $15.76M 5.96% | 9.91M | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 797.60K | SH | $12.52M 4.74% | 797.60K | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 830.95K | SH | $11.95M 4.52% | 830.95K | 0.00 | 0.00 |
CAMP4 THERAPEUTICS CORPSOLE | COM | 2.93M | SH | $11.71M 4.43% | 2.93M | 0.00 | 0.00 |
BIOHAVEN LTDSOLE | COM | 478.97K | SH | $11.51M 4.35% | 478.97K | 0.00 | 0.00 |
MOONLAKE IMMUNOTHERAPEUTICSSOLE | CLASS A ORD | 282.31K | SH | $11.03M 4.17% | 282.31K | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 736.60K | SH | $9.93M 3.76% | 736.60K | 0.00 | 0.00 |
TECTONIC THERAPEUTIC INCSOLE | COM | 511.66K | SH | $9.06M 3.43% | 511.66K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWSOLE | COM NEW | 497.27K | SH | $9.03M 3.41% | 497.27K | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COM | 939.30K | SH | $8.74M 3.30% | 939.30K | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 5.41M | SH | $7.41M 2.80% | 5.41M | 0.00 | 0.00 |
ARTIVA BIOTHERAPEUTICS INCSOLE | COM | 2.35M | SH | $7.06M 2.67% | 2.35M | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 357.73K | SH | $6.65M 2.52% | 357.73K | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 170K | SH | $6.44M 2.43% | 170K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | ORDINARY SHARES | 572.66K | SH | $6.32M 2.39% | 572.66K | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COM NEW | 1.05M | SH | $5.69M 2.15% | 1.05M | 0.00 | 0.00 |
VIKING THERAPEUTICS INCSOLE | COM | 189.59K | SH | $4.58M 1.73% | 189.59K | 0.00 | 0.00 |
VOR BIOPHARMA INCSOLE | COM | 6.36M | SH | $4.56M 1.73% | 6.36M | 0.00 | 0.00 |
SURROZEN INCSOLE | COM NEW | 310K | SH | $3.61M 1.37% | 310K | 0.00 | 0.00 |
PROTARA THERAPEUTICS INCSOLE | COM STK | 800K | SH | $3.41M 1.29% | 800K | 0.00 | 0.00 |
SCPHARMACEUTICALS INCSOLE | COM | 1.20M | SH | $3.16M 1.19% | 1.20M | 0.00 | 0.00 |
RALLYBIO CORPSOLE | COM | 3.63M | SH | $2.38M 0.90% | 3.63M | 0.00 | 0.00 |
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