Filed: 2/14/2025ACC: 0001085146-25-001687
📋 What this filing means
5AM VENTURE MANAGEMENT, LLC filed this quarterly 13F‑HR report disclosing 31 equity positions with a total reported market value of $419.05M. This filing provides a transparent view of the manager's long equity holdings as of the quarter end.
31
Positions
$419.05M
Total AUM (reported)
51.19M
Total Shares
Allocation by class
COM$312.76M74.6%
COM NEW$65.58M15.6%
CLASS A ORD$15.29M3.6%
SPONSORED ADS$13.92M3.3%
COM STK$4.22M1.0%
ORDINARY SHARES$4.01M1.0%
ADS$3.28M0.8%
Portfolio Concentration
Top 3$140.94M33.6%
4–10$137.42M32.8%
11–25$128.12M30.6%
Rest$12.56M3.0%
Top 3 weight
33.6%
Top 10 weight
66.4%
Voting Authority Distribution
Total shares with voting rights: 51.19M
Sole
Full voting authority
51.19M
shares
% of voting shares100.0%
Shared
Joint voting authority
0.00
shares
% of voting shares0.0%
None
No voting authority
0.00
shares
% of voting shares0.0%
Investment Discretion (by position count)
Sole31
Shared0
Other0
Dominant voting typeSole · 100.0% of voting shares
Institutional Holdings31
Rows:
ENTRADA THERAPEUTICS INC
SOLEShares4.41M
TypeSH
Market value$76.22M
18.19%
Sole
4.41M
Shared
0.00
None
0.00
ENLIVEN THERAPEUTICS INC
SOLEShares1.63M
TypeSH
Market value$36.67M
8.75%
Sole
1.63M
Shared
0.00
None
0.00
SKYE BIOSCIENCE INC
SOLEShares9.91M
TypeSH
Market value$28.05M
6.69%
Sole
9.91M
Shared
0.00
None
0.00
TECTONIC THERAPEUTIC INC
SOLEShares596.66K
TypeSH
Market value$27.55M
6.57%
Sole
596.66K
Shared
0.00
None
0.00
ARTIVA BIOTHERAPEUTICS INC
SOLEShares2.35M
TypeSH
Market value$23.72M
5.66%
Sole
2.35M
Shared
0.00
None
0.00
DIANTHUS THERAPEUTICS INC
SOLEShares1.03M
TypeSH
Market value$22.40M
5.35%
Sole
1.03M
Shared
0.00
None
0.00
BIOHAVEN LTD
SOLEShares478.97K
TypeSH
Market value$17.89M
4.27%
Sole
478.97K
Shared
0.00
None
0.00
PHARVARIS N V
SOLEShares797.60K
TypeSH
Market value$15.29M
3.65%
Sole
797.60K
Shared
0.00
None
0.00
MOONLAKE IMMUNOTHERAPEUTICS
SOLEShares282.31K
TypeSH
Market value$15.29M
3.65%
Sole
282.31K
Shared
0.00
None
0.00
CAMP4 THERAPEUTICS CORP
SOLEShares2.93M
TypeSH
Market value$15.28M
3.65%
Sole
2.93M
Shared
0.00
None
0.00
VIRIDIAN THERAPEUTICS INC
SOLEShares736.60K
TypeSH
Market value$14.12M
3.37%
Sole
736.60K
Shared
0.00
None
0.00
CENTESSA PHARMACEUTICALS PLC
SOLEShares830.95K
TypeSH
Market value$13.92M
3.32%
Sole
830.95K
Shared
0.00
None
0.00
ERASCA INC
SOLEShares5.41M
TypeSH
Market value$13.57M
3.24%
Sole
5.41M
Shared
0.00
None
0.00
PRAXIS PRECISION MEDICINES I
SOLEShares170K
TypeSH
Market value$13.08M
3.12%
Sole
170K
Shared
0.00
None
0.00
TYRA BIOSCIENCES INC
SOLEShares939.30K
TypeSH
Market value$13.06M
3.12%
Sole
939.30K
Shared
0.00
None
0.00
CELLDEX THERAPEUTICS INC NEW
SOLEShares497.27K
TypeSH
Market value$12.57M
3.00%
Sole
497.27K
Shared
0.00
None
0.00
EYEPOINT PHARMACEUTICALS INC
SOLEShares1.05M
TypeSH
Market value$7.82M
1.87%
Sole
1.05M
Shared
0.00
None
0.00
VIKING THERAPEUTICS INC
SOLEShares189.59K
TypeSH
Market value$7.63M
1.82%
Sole
189.59K
Shared
0.00
None
0.00
VOR BIOPHARMA INC
SOLEShares6.36M
TypeSH
Market value$7.06M
1.69%
Sole
6.36M
Shared
0.00
None
0.00
ANAPTYSBIO INC
SOLEShares357.73K
TypeSH
Market value$4.74M
1.13%
Sole
357.73K
Shared
0.00
None
0.00
AKERO THERAPEUTICS INC
SOLEShares165K
TypeSH
Market value$4.59M
1.10%
Sole
165K
Shared
0.00
None
0.00
SCPHARMACEUTICALS INC
SOLEShares1.20M
TypeSH
Market value$4.25M
1.01%
Sole
1.20M
Shared
0.00
None
0.00
PROTARA THERAPEUTICS INC
SOLEShares800K
TypeSH
Market value$4.22M
1.01%
Sole
800K
Shared
0.00
None
0.00
GH RESEARCH PLC
SOLEShares572.66K
TypeSH
Market value$4.01M
0.96%
Sole
572.66K
Shared
0.00
None
0.00
RALLYBIO CORP
SOLEShares3.63M
TypeSH
Market value$3.49M
0.83%
Sole
3.63M
Shared
0.00
None
0.00
| Issuer | Class | Shares | Type | Value / Portfolio % | Voting — Sole | Shared | None |
|---|---|---|---|---|---|---|---|
ENTRADA THERAPEUTICS INCSOLE | COM | 4.41M | SH | $76.22M 18.19% | 4.41M | 0.00 | 0.00 |
ENLIVEN THERAPEUTICS INCSOLE | COM | 1.63M | SH | $36.67M 8.75% | 1.63M | 0.00 | 0.00 |
SKYE BIOSCIENCE INCSOLE | COM NEW | 9.91M | SH | $28.05M 6.69% | 9.91M | 0.00 | 0.00 |
TECTONIC THERAPEUTIC INCSOLE | COM | 596.66K | SH | $27.55M 6.57% | 596.66K | 0.00 | 0.00 |
ARTIVA BIOTHERAPEUTICS INCSOLE | COM | 2.35M | SH | $23.72M 5.66% | 2.35M | 0.00 | 0.00 |
DIANTHUS THERAPEUTICS INCSOLE | COM | 1.03M | SH | $22.40M 5.35% | 1.03M | 0.00 | 0.00 |
BIOHAVEN LTDSOLE | COM | 478.97K | SH | $17.89M 4.27% | 478.97K | 0.00 | 0.00 |
PHARVARIS N VSOLE | COM | 797.60K | SH | $15.29M 3.65% | 797.60K | 0.00 | 0.00 |
MOONLAKE IMMUNOTHERAPEUTICSSOLE | CLASS A ORD | 282.31K | SH | $15.29M 3.65% | 282.31K | 0.00 | 0.00 |
CAMP4 THERAPEUTICS CORPSOLE | COM | 2.93M | SH | $15.28M 3.65% | 2.93M | 0.00 | 0.00 |
VIRIDIAN THERAPEUTICS INCSOLE | COM | 736.60K | SH | $14.12M 3.37% | 736.60K | 0.00 | 0.00 |
CENTESSA PHARMACEUTICALS PLCSOLE | SPONSORED ADS | 830.95K | SH | $13.92M 3.32% | 830.95K | 0.00 | 0.00 |
ERASCA INCSOLE | COM | 5.41M | SH | $13.57M 3.24% | 5.41M | 0.00 | 0.00 |
PRAXIS PRECISION MEDICINES ISOLE | COM NEW | 170K | SH | $13.08M 3.12% | 170K | 0.00 | 0.00 |
TYRA BIOSCIENCES INCSOLE | COM | 939.30K | SH | $13.06M 3.12% | 939.30K | 0.00 | 0.00 |
CELLDEX THERAPEUTICS INC NEWSOLE | COM NEW | 497.27K | SH | $12.57M 3.00% | 497.27K | 0.00 | 0.00 |
EYEPOINT PHARMACEUTICALS INCSOLE | COM NEW | 1.05M | SH | $7.82M 1.87% | 1.05M | 0.00 | 0.00 |
VIKING THERAPEUTICS INCSOLE | COM | 189.59K | SH | $7.63M 1.82% | 189.59K | 0.00 | 0.00 |
VOR BIOPHARMA INCSOLE | COM | 6.36M | SH | $7.06M 1.69% | 6.36M | 0.00 | 0.00 |
ANAPTYSBIO INCSOLE | COM | 357.73K | SH | $4.74M 1.13% | 357.73K | 0.00 | 0.00 |
AKERO THERAPEUTICS INCSOLE | COM | 165K | SH | $4.59M 1.10% | 165K | 0.00 | 0.00 |
SCPHARMACEUTICALS INCSOLE | COM | 1.20M | SH | $4.25M 1.01% | 1.20M | 0.00 | 0.00 |
PROTARA THERAPEUTICS INCSOLE | COM STK | 800K | SH | $4.22M 1.01% | 800K | 0.00 | 0.00 |
GH RESEARCH PLCSOLE | ORDINARY SHARES | 572.66K | SH | $4.01M 0.96% | 572.66K | 0.00 | 0.00 |
RALLYBIO CORPSOLE | COM | 3.63M | SH | $3.49M 0.83% | 3.63M | 0.00 | 0.00 |
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